Postprandial Vascular Reactivity in Obese and Normal Weight Young Adults

摘要: As humans spend a significant amount of time in the postprandial state, we examined whether vascular reactivity (a key indicator cardiovascular health) was different after high-fat meal 11 obese (median BMI 46.4, age 32.1 +/- 6.3 years, 7 men) and normal weight 22.6) age- sex-matched controls. At baseline 1 3 h postmeal, blood pressure (BP), heart rate (HR), reactive hyperemia peripheral artery tonometry (RH-PAT) index, radial augmentation index adjusted for HR (AIx75), brachial pulse wave velocity (PWV(b)), glucose, insulin, total high-density lipoprotein (HDL) cholesterol, triglycerides were measured. Brachial flow-mediated dilatation (FMD) and, by venous plethysmography, resting hyperemic forearm flows (FBFs) measured at h. baseline, subjects had higher systolic BP, HR, FBF, insulin equivalent FMD, RH-PAT, AIx75, PWV(b), triglycerides, lower HDL cholesterol. In lean subjects, FMD not significantly (6.2 1.7 to 5.8 4.3% 4.7 4.1 4.3 3.9% weight, P = 0.975 group x time). The did produce changes PWV(b) either (P > 0.1 effect interactions). conclusion, responses are similar young adults. An exaggerated alteration is thus unlikely contribute importantly increased risk obesity.