Type C-chronic hepatitis patients who had autoimmune phenomenon and developed jaundice during interferon therapy.

摘要: Of a total of 2342 patients with type-C chronic hepatitis treated interferon (IFN) at this hospital, 3 developed jaundice during the course IFN therapy, but all them exhibited negative conversion C virus (HCV)-RNA following readministration IFN. All were assessed as having "probable autoimmune (AIH)" in accordance AIH scoring system, indicating association an "autoimmune phenomenon". Readministration low-dose induced activation phenomenon, leading to fulminant hepatocellular impairment. As result, HCV-RNA content dropped dramatically, possibly contributing noted At present, no adequate therapy has been established for manifestations. However, conclusion, our findings suggested that: should be frontline regiment: (1). if autoantibody titers are low or rated AIH" lower strong link (2). is expected efficacious on basis genotype level; even there acute exacerbation hepatitis, re-administered level subsequently.