Childhood and Adolescent Passive Smoking and the Risk of Female Lung Cancer

摘要: BACKGROUND Few studies have reported the relationship between passive smoking (PS) in early life and risk of lung cancer. This study was done to evaluate female cancer from PS, especially that during childhood adolescence. METHODS Using household exposure tobacco smoke as an estimate a 1:1 paired case-control conducted Harbin, China. We interviewed 114 primary cases, aged 30-69 years, their hospital-based controls. The controls were non-cancer patients, selected same hospital matched on age (+/- 5 years), residential area status over lifetime. There 59 pairs who ever smoked 55 never smoked. Information PS collected by residence for each following periods: 0-6, 7-14, 15-22, 23-30 31-69 years. RESULTS Household significantly increases those exposed at ages 22 or younger, also increased non-smoking when under 15 Exposure maternal 14 younger about 170% (odds ratio, OR 2.7, 95% confidence interval [CI]: 1.49-4.88), but not paternal (OR 1.40, 95%CI: 0.92-2.50). highest seven 3.46, 1.80-6.65) significant 7-14 3.08, CI: 1.62-5.57) 15-22 3.10, 1.52-6.31) Under 23 with amount (P < 0.001). Of note, all five periods similar studied. CONCLUSIONS particularly childhood, assessment should be different exposure.