Prevalence and correlates of obstructive lung disease among people who inject drugs, San Diego, California.

摘要: Abstract Background Pulmonary tissue damage leading to obstructive lung disease (OLD) could result from intravenous administration of insoluble particles found in illicit drugs. This study described the prevalence and identified correlates OLD among people who inject drugs (PWID). Methods In 2012–2016, a community-based cohort PWID had injected within past month were enrolled assess HIV, hepatitis C virus (HCV) andMycobacterium tuberculosis (Mtb) infections their related risk factors. Data obtained through face-to-face interviews, serological testing spirometry. Baseline data used for cross-sectional analysis OLD, defined as FEV1/FVC Results Among 516 participants complete spirometry interview results, mean age was 43.3 years, 73.6 % male, 9.5 Black, 91.1 smoked cigarettes 18.2 OLD. Few (9.6 %) with reported previous diagnosis COPD although many (44.7 symptoms. Black race (AOR = 2.66, 95 %CI: 1.37, 5.17), pack-years 1.06/5 1.01, 1.12), duration injection drug use 1.13, 1.27) independently associated after controlling age. Conclusions The high this cigarette smoking—known addition, increased greater use, suggesting link between cumulative exposure Further examination these adulterants pathology are needed.