Interferon-γ gene and interferon-γ receptor-1 gene polymorphisms in children with tuberculosis from Turkey
作者： Huseyin Onay , Aslihanyilmaz Ekmekci , Burak Durmaz , Eren Sayin , Hese Cosar
DOI: 10.3109/00365540903253502
关键词:
摘要: AbstractMacrophage activation by interferon-γ (IFN-γ) is important in host resistance to tuberculosis (TB). In this study, the relationships of +874 T/A polymorphism first intron IFN-γ gene and intronic (CA)n polymorphic microsatellite marker receptor 1 (IFN-γR1) TB susceptibility were investigated children. Forty children with 67 age-matched controls included. There no significant differences between allele frequencies genotype patient control groups for gene. Differences that not statistically found group allelic markers (170 180) IFN-γR1 The incidence 170 was higher patients (30.9%) than (17.4%), whereas 180 be more common (9% vs 1.2%). conclusion, association observed T/...
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