Pharmacokinetics and pharmacodynamics of cisplatin after intraoperative hyperthermic intraperitoneal chemoperfusion (HIPEC).

摘要: BACKGROUND HIPEC is a new treatment modality for abdominal cancers that combines cytoreductive surgery with Hyperthermic, Intraoperative Peritoneal Chemotherapy, followed by systemic chemotherapy. A significant survival benefit has been shown compared therapy alone. However, it not clear what the contribution of i.p. drug delivery and influence mild hyperthermia on uptake cisplatin in tumors. MATERIALS AND METHODS We used peritoneal perfusion system rats to compare pharmacokinetics pharmacodynamics cisplatin, after normothermic (37 degrees C/90 minutes) hyperthermic (40 intra-peritoneal perfusion, an bolus injection. RESULTS Hyperthermic 15 micrograms/ml (in 200 ml) gave equivalent plasma levels maximum tolerated dose (MTD) injection 4 mg/kg (36 20 ml). The concentration small (1-5 mm) tumors was also comparable both these treatments, perfusion. CONCLUSION Mild did improve tumors, relative or