Role of T Follicular Helper cells in Multiple Sclerosis
作者： Nathalie Schmitt
DOI:
关键词:
摘要: Multiple Sclerosis (MS) is a chronic, inflammatory and neurodegenerative disease which results from the destruction of myelin associated collateral tissue damage within central nervous system (CNS). MS highly diverse with different clinical profiles. During past decade, several new treatment options have been introduced, but no completely stops progression. Therefore deeper understanding mechanism necessary to develop novel therapeutic strategies. While yet be proven, there evidence suggesting involvement T follicular helper (Tfh) cells, CD4 cell subset specialized for provision help B in pathogenesis MS. In this review, I will discuss potential pathogenic roles Tfh cells course Journal Nature Science, 1(7):e139, 2015.
jnsci.org参考文章(51)
L Steinman, D Solomon, R V Rouse, S Sriram, Identification of T cell subsets and B lymphocytes in mouse brain experimental allergic encephalitis lesions. Journal of Immunology. ,vol. 129, pp. 1649- 1651 ,(1982)
Federica Sallusto, Daniela Impellizzieri, Camilla Basso, Alice Laroni, Antonio Uccelli, Antonio Lanzavecchia, Britta Engelhardt, T-cell trafficking in the central nervous system Immunological Reviews. ,vol. 248, pp. 216- 227 ,(2012) , 10.1111/J.1600-065X.2012.01140.X
Javad Rasouli, Bogoljub Ciric, Jaime Imitola, Patricia Gonnella, Daniel Hwang, Kedar Mahajan, Elisabeth R. Mari, Farinaz Safavi, Thomas P. Leist, Guang-Xian Zhang, Abdolmohamad Rostami, Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-β Therapy The Journal of Immunology. ,vol. 194, pp. 5085- 5093 ,(2015) , 10.4049/JIMMUNOL.1403243
W Ridgway, L Steinman, S Brocke, C Dinisco, D Dalton, I A Ferber, C G Fathman, C Taylor-Edwards, Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). Journal of Immunology. ,vol. 156, pp. 5- 7 ,(1996)
Stephen Sawcer, Garrett Hellenthal, None, The major histocompatibility complex and multiple sclerosis: a smoking gun? Brain. ,vol. 134, pp. 638- 640 ,(2011) , 10.1093/BRAIN/AWQ384
Randolph J. Noelle, Brigit G. Durell, Burkhard Becher, Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. Journal of Clinical Investigation. ,vol. 110, pp. 493- 497 ,(2002) , 10.1172/JCI15751
A. Corcione, S. Casazza, E. Ferretti, D. Giunti, E. Zappia, A. Pistorio, C. Gambini, G. L. Mancardi, A. Uccelli, V. Pistoia, Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 11064- 11069 ,(2004) , 10.1073/PNAS.0402455101
Stefan Haak, Andrew L. Croxford, Katharina Kreymborg, Frank L. Heppner, Sandrine Pouly, Burkhard Becher, Ari Waisman, IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice Journal of Clinical Investigation. ,vol. 119, pp. 61- 69 ,(2008) , 10.1172/JCI35997
Richard M. Ransohoff, David A. Hafler, Claudia F. Lucchinetti, Multiple sclerosis—a quiet revolution Nature Reviews Neurology. ,vol. 11, pp. 134- 142 ,(2015) , 10.1038/NRNEUROL.2015.14
Michela Locci, Colin Havenar-Daughton, Elise Landais, Jennifer Wu, Mark A Kroenke, Cecilia L Arlehamn, Laura F Su, Rafael Cubas, Mark M Davis, Alessandro Sette, Elias K Haddad, Pascal Poignard, Shane Crotty, None, Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses Immunity. ,vol. 39, pp. 758- 769 ,(2013) , 10.1016/J.IMMUNI.2013.08.031