The murine Hox-2 genes display dynamic dorsoventral patterns of expression during central nervous system development.

摘要: This report demonstrates that the genes in murine Hox-2 cluster display spatially and temporally dynamic patterns of expression transverse plane developing CNS. All exhibit changing reflect events during ontogeny The observed correlates with timing location birth major classes neurons spinal cord. Therefore, it is suggested act to confer rostrocaudal positional information on each successive class newly born neurons. analysis has also revealed a striking dorsal restriction cord between 12.5 14.5 days gestation, which does not appear correlate any morphological structure. cellular retinol binding protein (CRBP) shows complementary ventral staining pattern, suggesting number are dorsoventrally restricted development been compared Hox-3.1 gene, exhibits markedly different dorsoventral pattern expression. suggests that, while Hox clusters may have similar A-P domains expression, they responding patterning signals