The rise of genomic profiling in ovarian cancer.
作者： Rebecca A. Previs , Anil K. Sood , Gordon B. Mills , Shannon N. Westin
DOI: 10.1080/14737159.2016.1259069
关键词:
摘要: ABSTRACTIntroduction: Next-generation sequencing and advances in ‘omics technology have rapidly increased our understanding of the molecular landscape epithelial ovarian cancers.Areas covered: Once characterized only by histologic appearance clinical behavior, we now understand many phenotypes that underlie different cancer subtypes. While current approach to treatment involves standard cytotoxic therapies after cytoreductive surgery for all cancers regardless or characteristics, focus has shifted beyond a ‘one size fits all’ cancer.Expert commentary: Genomic profiling offers potentially ‘actionable’ opportunities development targeted more individualized with concomitant improved outcomes decreased toxicity.
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