A morphological study of 608 cases of canine malignant lymphoma in France with a focus on comparative similarities between canine and human lymphoma morphology.

摘要: This study reports cytomorphological, histomorphological, and immunological characterization of 608 biopsy cases canine malignant lymphoma, with epidemiological clinical data, collected from 7 French veterinary pathology laboratories. It compares morphological characteristics lymphoma in canines, per the updated Kiel classification system, those reported humans, World Health Organization (WHO) system. Of tumors described, 24.5% 75.5% were classified as low- high-grade lymphomas, respectively. Presenting signs included generalized or localized lymphadenopathy (82.4%) extranodal diseases (17.6%) involving skin (12.34%) other sites (5.26%). Immunohistochemistry confirmed 63.8% B-cell (CD3-, CD79a+), 35.4% T-cell (CD3+, CD79a-), 0.8% null-cell CD79a-) lymphomas. Most (38.49%) centroblastic polymorphic subtype; most (8.55%), pleomorphic mixed large subtypes. Some showed morphologic consistent follicular lymphomas marginal zone Revised European American Classification Lymphoid Neoplasms WHO systems human Unusual subtypes an atypical small (0.66%), Burkitt-type (1.64%), plasmacytoid (0.99%), mediastinal anaplastic (0.16%). a previously undescribed immunoblastic type (1.15%), rare low-grade prolymphocytic (0.16%), recently described entity--aggressive granulocytic large-cell Marginal common (10.86%); (0.49%). Canine primary cutaneous present (11.84%). There was no significant difference between B- regard to age sex. A overrepresentation Boxers (24.19%) found for