Downstream of mTOR: Translational Control of Cancer
作者： Ryan J. O. Dowling , Nahum Sonenberg
DOI: 10.1007/978-1-60327-271-1_10
关键词:
摘要: mTOR is a key regulator of number critical cellular processes including growth, proliferation, cytoskeletal organization, and differentiation. mediates its effects on these by regulating mRNA translation initiation via phosphorylation major downstream targets: the 4E binding proteins (4E-BPs) ribosomal protein S6 kinases. Dysregulation signalling leads to increased growth proliferation implicated in human cancers. In particular, associated with cancers that are characterized loss or mutations tumour suppressors such as LKB1, PTEN, TSC1/2, which responsible for suppressing PI3K/AKT pathway. The regulation will be focus this chapter. role translational machinery oncogenesis discussed.
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sci-hub.st 参考文章(106)
John WB Hershey, Michael Mathews, Nahum Sonenberg, None, Translational control of gene expression Cold Spring Harbor Laboratory Press. ,(2000)
Nahum Sonenberg, Michael B. Mathews, John W. B. Hershey, Translational control in biology and medicine Cold Spring Harbor Laboratory Press. ,(2007)
R Duncan, J W Hershey, Regulation of initiation factors during translational repression caused by serum depletion. Covalent modification. Journal of Biological Chemistry. ,vol. 260, pp. 5493- 5497 ,(1985) , 10.1016/S0021-9258(18)89049-4
Gareth J. Browne, Christopher G. Proud, Regulation of peptide-chain elongation in mammalian cells. FEBS Journal. ,vol. 269, pp. 5360- 5368 ,(2002) , 10.1046/J.1432-1033.2002.03290.X
Maarit Bärlund, Outi Monni, Juha Kononen, Guido Sauter, Olli-P. Kallioniemi, Anne Kallioniemi, Joachim Torhorst, Robert Cornelison, Multiple genes at 17q23 undergo amplification and overexpression in breast cancer. Cancer Research. ,vol. 60, pp. 5340- 5344 ,(2000)
Mathieu Miron, Javier Verdú, Pascal E.D. Lachance, Morris J. Birnbaum, Paul F. Lasko, Nahum Sonenberg, The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nature Cell Biology. ,vol. 3, pp. 596- 601 ,(2001) , 10.1038/35078571
Gingras Ac, Pause A, Rousseau D, Sonenberg N, The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth. Oncogene. ,vol. 13, pp. 2415- 2420 ,(1996)
Akseli Hemminki, David Markie, Ian Tomlinson, Egle Avizienyte, Stina Roth, Anu Loukola, Graham Bignell, William Warren, Maria Aminoff, Pia Höglund, Heikki Järvinen, Paula Kristo, Katarina Pelin, Maaret Ridanpää, Reijo Salovaara, Tumi Toro, Walter Bodmer, Sylviane Olschwang, Anne S Olsen, Michael R Stratton, Albert De La Chapelle, Lauri A Aaltonen, None, A serine/threonine kinase gene defective in Peutz–Jeghers syndrome Nature. ,vol. 391, pp. 184- 187 ,(1998) , 10.1038/34432
C. David James, Guo Jun Wu, Junqi Qian, Robert B. Jenkins, Fergus J. Couch, Xiao Yang Wang, Localization of PS6K to chromosomal region 17q23 and determination of its amplification in breast cancer. Cancer Research. ,vol. 59, pp. 1408- 1411 ,(1999)
Michael John Fry, Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play? Breast Cancer Research. ,vol. 3, pp. 304- 312 ,(2001) , 10.1186/BCR312