Cell adhesion receptors in lymphoma dissemination
作者： Paul Drillenburg , Steven T. Pals
关键词:
摘要: Regulated lymphocyte trafficking is essential for the control and integration of systemic immune responses. This homing process disperses immunologic repertoire, guides subsets to specialized microenvironments that their differentiation survival, targets effector cells sites antigenic insult. review discusses data indicating adhesion receptors regulating normal lymphocytes are also expressed functionally active in malignant counterparts, non-Hodgkin lymphomas. These "homing receptors" appear mediate highly tissue-specific dissemination specific lymphoma subtypes, such as lymphomas mucosa-associated lymphoid tissues skin. Furthermore, a result capability enhance transduce signals into cell, promoting cell growth may contribute aggressiveness. Taken together, offer framework understanding routes suggest receptors, specifically those CD44 family, present useful tools predict prognosis patients with (Blood. 2000;95:1900-1910)
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