Micro-RNAs in cognition and cognitive disorders: Potential for novel biomarkers and therapeutics.
作者： Bisrat T. Woldemichael , Isabelle M. Mansuy
DOI: 10.1016/J.BCP.2015.11.021
关键词:
摘要: Micro-RNAs (miRNAs) are small regulatory non-coding RNAs involved in the regulation of many biological functions. In brain, they have distinct expression patterns depending on region, cell-type and developmental stage. Their profile is altered by neuronal activation response to behavioral training or chemical/electrical stimulation. The dynamic changes miRNA level regulate genes required for cognitive processes such as learning memory. addition, dysfunctions dementias, levels miRNAs perturbed, not only brain areas affected pathology, but also peripheral body fluids serum cerebrospinal fluid. This presents an opportunity utilize biomarkers early detection assessment dysfunctions. Further, since target pathways, may represent key molecular signatures that can help understand mechanisms disorders development potential therapeutic agents.
core.ac.uk
uzh.ch
sci-hub.se 参考文章(92)
Nobuyoshi Kosaka, Haruhisa Iguchi, Yusuke Yoshioka, Fumitaka Takeshita, Yasushi Matsuki, Takahiro Ochiya, Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells Journal of Biological Chemistry. ,vol. 285, pp. 17442- 17452 ,(2010) , 10.1074/JBC.M110.107821
Shelly A. Buffington, Wei Huang, Mauro Costa-Mattioli, Translational Control in Synaptic Plasticity and Cognitive Dysfunction Annual Review of Neuroscience. ,vol. 37, pp. 17- 38 ,(2014) , 10.1146/ANNUREV-NEURO-071013-014100
Stephen M. Eacker, Matthew J. Keuss, Eugene Berezikov, Valina L. Dawson, Ted M. Dawson, Neuronal Activity Regulates Hippocampal miRNA Expression PLoS ONE. ,vol. 6, pp. e25068- ,(2011) , 10.1371/JOURNAL.PONE.0025068
Ryan J. Taft, Michael Pheasant, John S. Mattick, The relationship between non-protein-coding DNA and eukaryotic complexity BioEssays. ,vol. 29, pp. 288- 299 ,(2007) , 10.1002/BIES.20544
Mareike Müller, H. Bea Kuiperij, Jurgen A. Claassen, Benno Küsters, Marcel M. Verbeek, MicroRNAs in Alzheimer's disease: differential expression in hippocampus and cell-free cerebrospinal fluid Neurobiology of Aging. ,vol. 35, pp. 152- 158 ,(2014) , 10.1016/J.NEUROBIOLAGING.2013.07.005
M. Agostini, P. Tucci, J. R. Steinert, R. Shalom-Feuerstein, M. Rouleau, D. Aberdam, I. D. Forsythe, K. W. Young, A. Ventura, C. P. Concepcion, Y.-C. Han, E. Candi, R. A. Knight, T. W. Mak, G. Melino, microRNA-34a regulates neurite outgrowth, spinal morphology, and function Proceedings of the National Academy of Sciences of the United States of America. ,vol. 108, pp. 21099- 21104 ,(2011) , 10.1073/PNAS.1112063108
Gerhard M. Schratt, Fabian Tuebing, Elizabeth A. Nigh, Christina G. Kane, Mary E. Sabatini, Michael Kiebler, Michael E. Greenberg, A brain-specific microRNA regulates dendritic spine development Nature. ,vol. 439, pp. 283- 289 ,(2006) , 10.1038/NATURE04367
Andreas G. Bader, miR-34 - a microRNA replacement therapy is headed to the clinic. Frontiers in Genetics. ,vol. 3, pp. 120- 120 ,(2012) , 10.3389/FGENE.2012.00120
Neil R. Smalheiser, The RNA-centred view of the synapse: non-coding RNAs and synaptic plasticity Philosophical Transactions of the Royal Society B. ,vol. 369, pp. 20130504- ,(2014) , 10.1098/RSTB.2013.0504
Eduardo Gascon, Kelleen Lynch, Hongyu Ruan, Sandra Almeida, Jamie M Verheyden, William W Seeley, Dennis W Dickson, Leonard Petrucelli, Danqiong Sun, Jian Jiao, Hongru Zhou, Mira Jakovcevski, Schahram Akbarian, Wei-Dong Yao, Fen-Biao Gao, Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia Nature Medicine. ,vol. 20, pp. 1444- 1451 ,(2014) , 10.1038/NM.3717