Piezoelectric Mass‐Sensing Devices as Biosensors—An Alternative to Optical Biosensors?

摘要: In the early days of electronic communication—as a result limited number quartz resonators available—frequency adjustment was accomplished by pencil mark depositing foreign mass layer on crystal. 1959, Sauerbrey showed that shift in resonance frequency thickness-shear-mode is proportional to deposited mass. This starting point for development new generation piezoelectric mass-sensitive devices. However, it powerful oscillator circuits were capable operating thickness shear mode fluids enabled this technique be introduced into bioanalytic applications. last decade adsorption biomolecules functionalized surfaces turned one paramount applications transducers. These include study interaction DNA and RNA with complementary strands, specific recognition protein ligands immobilized receptors, detection virus capsids, bacteria, mammalian cells, but not least complete immunosensors. Piezoelectric transducers allow label-free molecules; they are more than mere sensors since sensor response also influenced interfacial phenomena, viscoelastic properties adhered biomaterial, surface charges adsorbed molecules, roughness. insights have recently been used investigate adhesion liposomes, proteins onto surfaces, thus allowing determination morphological changes cells as pharmacological substances water content biopolymers without employing labor-intense techniques. future will show whether quartz-crystal microbalance assert itself against established devices such plasmon spectroscopy interferometry.