The biology of conformation in the regulation of the senescent and transformed cell phenotypes.

摘要: The cytoskeleton and the composition of cytoplasmic membrane normal somatic cells are modified during proliferation in vitro. loss proliferative potential serial divisions is due part to these structural modifications that induce a decline cell conformational flexibility. During viral transformation, changes affinity its matrix neighboring increase migratory capability maintaining flexibility; this way can proliferate densities where stop dividing. Cell proliferation, transformed phenotype, differentiation could be modulated by changing electric charge substratum. Results support view biology conformation crucial for expression properties.