Analysis of Labeled Quantitative Mass Spectrometry Proteomics Data

摘要: Proteomics has an important role in biomedical research. Using mass spectrometry (MS), researchers are able to identify proteins on a large scale. Mass spectrometers measure spectra of peptides the basis which software packages can infer protein detection. By tagging from distinct samples with heavy and light labels, relative abundances different conditions compared, e.g., healthy versus diseased individuals. The quantification complex samples, monitoring specific post-translational modification (PTM) changes, identification biomarkers pose challenges experimentalists algorithmic statistical techniques applied.