Concise Construction of the Tricyclic Core of Bullataketals Enabled by a Biomimetic Intermolecular (3 + 3) Type Cycloaddition.
作者： Haibo Tan , Hongxin Liu , Xinzheng Chen , Yunfei Yuan , Kai Chen
DOI: 10.1021/ACS.ORGLETT.5B01970
关键词:
摘要: A remarkable TFA-mediated method for the construction of a biologically interesting tricyclic ketal skeleton was uncovered by starting from variety readily available acylphloroglucinol and diacylphloroglucinol substrates. This approach, which mimics biosynthetic olefin isomerization/hemiacetalization/dehydration/(3 + 3) type cycloaddition sequence through 2H-furan-1-ium intermediate, establishes viable synthetic strategy efficient synthesis bullataketals’ analogs.
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