Synthesis of the acylphloroglucinols rhodomyrtone and rhodomyrtosone B
作者： Marius Morkunas , Linda Dube , Friedrich Götz , Martin E. Maier
DOI: 10.1016/J.TET.2013.07.091
关键词:
摘要: Abstract In a sequential three-component coupling syncarpic acid, 3-methylbutanal and an acylated phloroglucinol were combined to the hydroxy ketone 3 . Acid catalysis converted directly natural product rhodomyrtosone B ( 2 ). The other isomer, antibiotic rhodomyrtone 1 ) was obtained from in sequence of acid-catalyzed cyclization, retro Friedel–Crafts reaction, reacylation. preliminary assays both compounds showed potent activity.
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