Iron homeostasis and anemia markers in early breast cancer

摘要: Iron plays a fundamental role in cell life and its concentration living organisms is precisely regulated. Different molecules for iron storage transport are used to maintain intracellular homeostasis which often altered cancer cells. Specifically, recent studies have demonstrated that breast cells, the expression/activity of several iron-related proteins, such as ferritin, hepcidin ferroportin, deregulated these alterations may prognostic impact patients with cancer. Moreover, regulate metabolism could become therapeutic targets. This review focuses on findings particularly development new biomarkers be clinical routine diagnosis, prognosis management cancer-associated anemia well monitoring personalized treatments.