FTO polymorphisms in oceanic populations
作者： Jun Ohashi , Izumi Naka , Ryosuke Kimura , Kazumi Natsuhara , Taro Yamauchi
DOI: 10.1007/S10038-007-0198-2
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摘要: It has been suggested that Neel’s “thrifty genotype” model may account for high body weights in some Oceanic populations, which presumably arose modern times. In European common variants (rs1421085-C, rs17817449-G, and rs9939609-A) the fat mass obesity (FTO associated) were recently found to be associated with index (BMI) or obesity. this study, we investigated population frequencies of these six populations (Melanesians, Micronesians, Polynesians) tested an association BMI. Unlike displayed no significant between FTO polymorphisms These strong linkage disequilibrium. The ranged 4.2 30.3% similar those southeast east Asian populations. Our study generated evidence support thrifty genotype hypothesis
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