Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta.
作者： Lars-Oliver Essen , Olga Perisic , Robert Cheung , Matilda Katan , Roger L. Williams
DOI: 10.1038/380595A0
关键词:
摘要: Mammalian phosphoinositide-specific phospholipase C enzymes (PI-PLC) act as signal transducers that generate two second messengers, inositol-1,4,5-trisphosphate and diacylglycerol. The 2.4-A structure of delta 1 reveals a multidomain protein incorporating modules shared by many signalling proteins. suggests mechanism for membrane attachment Ca2+-dependent hydrolysis second-messenger precursors. regulation reversible association PI-PLC may serve model understanding other involved in phospholipid signalling.
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