Chemogenomics: A Discipline at the Crossroad of High Throughput Technologies, Biomarker Research, Combinatorial Chemistry, Genomics, Cheminformatics, Bioinformatics and Artificial Intelligence.

摘要: Chemogenomics is the study of interaction functional biological systems with exogenous small molecules, or in broader sense intersection and chemical spaces. requires expertises biology, chemistry computational sciences (bioinformatics, cheminformatics, large scale statistics machine learning methods) but it more than simple apposition each these disciplines. Biological entities interacting molecules can be isolated proteins elaborate systems, from single cells to complete organisms. The space therefore analyzed at various postgenomic levels (genomic, transcriptomic, proteomic any phenotypic level). partially real, corresponding commercial academic collections compounds, virtual, possibly synthesizable. Synthetic has developed novel strategies allowing a physical exploration this universe possibilities. A major challenge cheminformatics charter virtual using realistic constraints (bioavailability, druggability, structural information). descendent conventional pharmaceutical approaches, since involves screening chemolibraries for their effect on targets, benefits advances enabling technologies introduction new markers. Screening was originally motivated by rigorous discovery drugs, neglecting throwing away molecule that would fail meet standards required therapeutic treatment. It now basis might not directly used as which have an immense potential basic research, probes explore increasing number phenomena. Concerns about environmental impact industry open fields research chemogenomics.