Integrative Systems Biology II—Molecular Biology: Phase 2 Lead Discovery and In Silico Screening
作者： Aleš Prokop , Seth Michelson
DOI: 10.1007/978-94-007-2849-3_4
关键词: Systems biology 、 Flux balance analysis 、 High-throughput screening 、 Synthetic biology 、 Identification (biology) 、 Biology 、 Computational biology 、 Chemogenomics 、 In silico 、 Biological network
摘要: Many different OMICs/HTS techniques now allow huge amounts of molecular signatures to be collected and then analysed further by system tools. Among them, ChIP-on-chip is used investigate interactions between proteins DNA in vivo. Chemogenomics, morphogenics synthetic biology are only the early stages development, but may contribute target identification. A key SB tool, reconstruction biological networks, represents an emerging field, undergoing explosive expansion, will likely enable efficient mapping gene onto function.
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sci-hub.se 参考文章(35)
Ting-Fung Chan, X F Steven Zheng, Chemical genomics: a systematic approach in biological research and drug discovery. Current Issues in Molecular Biology. ,vol. 4, pp. 33- 43 ,(2002)
Victoria J. Nikiforova, Lothar Willmitzer, Network visualization and network analysis Experientia Supplementum. ,vol. 97, pp. 245- 275 ,(2007) , 10.1007/978-3-7643-7439-6_11
Sung-Hoon Jun, Tae Gyun Kim, Changill Ban, DNA mismatch repair system. Classical and fresh roles. FEBS Journal. ,vol. 273, pp. 1609- 1619 ,(2006) , 10.1111/J.1742-4658.2006.05190.X
Andrea Sackmann, Monika Heiner, Ina Koch, Application of Petri net based analysis techniques to signal transduction pathways BMC Bioinformatics. ,vol. 7, pp. 482- 482 ,(2006) , 10.1186/1471-2105-7-482
Emanuel F. Petricoin, Claudio Belluco, Robyn P. Araujo, Lance A. Liotta, The blood peptidome: a higher dimension of information content for cancer biomarker discovery Nature Reviews Cancer. ,vol. 6, pp. 961- 967 ,(2006) , 10.1038/NRC2011
Mario A Marchisio, Jörg Stelling, Computational design tools for synthetic biology. Current Opinion in Biotechnology. ,vol. 20, pp. 479- 485 ,(2009) , 10.1016/J.COPBIO.2009.08.007
Yiannis N Kaznessis, Models for synthetic biology BMC Systems Biology. ,vol. 1, pp. 47- 47 ,(2007) , 10.1186/1752-0509-1-47
Eric Marechal, Chemogenomics: A Discipline at the Crossroad of High Throughput Technologies, Biomarker Research, Combinatorial Chemistry, Genomics, Cheminformatics, Bioinformatics and Artificial Intelligence. Combinatorial Chemistry & High Throughput Screening. ,vol. 11, pp. 583- 586 ,(2008) , 10.2174/138620708785739961
Sergey B. Zotchev, Alla V. Stepanchikova, Anastasia P. Sergeyko, Boris N. Sobolev, Dmitrii A. Filimonov, Vladimir V. Poroikov, Rational Design of Macrolides by Virtual Screening of Combinatorial Libraries Generated through in Silico Manipulation of Polyketide Synthases Journal of Medicinal Chemistry. ,vol. 49, pp. 2077- 2087 ,(2006) , 10.1021/JM051035I
Jason A Papin, Bernhard O Palsson, Topological analysis of mass-balanced signaling networks: a framework to obtain network properties including crosstalk. Journal of Theoretical Biology. ,vol. 227, pp. 283- 297 ,(2004) , 10.1016/J.JTBI.2003.11.016