Chapter 11 What is Functional Genomics Teaching us about Intraocular Pressure Regulation and Glaucoma

摘要: Publisher Summary Glaucoma is a complex disease characterized by the degeneration of optic nerve and subsequent loss vision. The affects large number people, especially those among older population. causes leading to development glaucoma can be result dysfunction several tissues. major risk for elevated intraocular pressure that consequence an improper regulation aqueous humor outflow in anterior segment eye (ciliary body trabecular meshwork). Elevated turn, posterior exerting mechanical strain on provoking deformation, distortion axonal flow, death cells (lamina cribrosa retinal ganglion cells). function any given tissue governed expression its genes. Functional genomics offers invaluable tool identify molecular differences affecting under conditions associated with glaucoma. This chapter discusses such changes. Because wide scope project, this briefly studies all tissues then concentrates conducted meshwork, keeper resistance. It analyzes correlates internal data other laboratories builds signature meshwork pathophysiology. identifies presents set 40 These include new genes involved known physiology representative processes mechanisms.