Quantitative angiographic morphology of coronary stenoses leading to myocardial infarction or unstable angina.

摘要: Identification of a characteristic morphology coronary stenosis likely to result in myocardial infarction would facilitate the prospective evaluation infarct prevention strategies and identification high-risk patients. We postulated that lesions associated with recent or unstable angina have an angiographic suggesting disruption atherosclerotic plaque appear morphologically different from chronic stable angina. To test this hypothesis, quantitative angiography (Brown-Dodge method) was performed 15 patients 4 30 days after infarction, 10 abrupt onset single-vessel disease, without prior infarction. Serial arterial diameters (20 40) within each lesion were determined degree luminal irregularity quantitated by calculation "ulceration" index. The majority all analyzed resulted severe (mean 78% area stenosis, groups). Despite small differences mean severity among groups, overlap compromise prevented precise classification based on percent minimum cross-sectional area. ulceration index infarct-related vessel those acute 0.62 +/- 0.05 (+/- SEM) 0.61 0.03, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)