Morphologic and physiologic validation of quantitative coronary arteriography utilizing digital methods

摘要: To assess the in-vivo performance of a coronary quantitation program, 16 dogs were instrumented with precision-drilled, plastic cylinders to create intraluminal stenoses ranging from 0.83 mm 1.83 mm. Biplane, on-line digital angiograms and cineangiograms obtained. The images analyzed in nonsubtracted subtracted modes. Cineangiograms digitized quantitated by same computer program. There was an excellent correlation between known measured minimal diameter (r = 0.87−0.98, s.e.e. 0.09−0.24 mm). Inter- intraobserver variability analysis showed high reproducibility 0.90−0.97, 0.12−0.23 best results both analyses achieved imaging worst cineradiography. Measures percent stenosis, area stenosis (geometric videometric) absolute cross-sectional all highly correlated independent measures actual flow reserve. This study provides direct, in-vivo, anatomical physiological validation new rapid method suitable for cineangiograms.