Thyroid hormone suppression of pituitary hormone gene expression.

摘要: T3 suppression of TSH subunit gene transcription is an important step in maintaining thyroid hormone homeostasis, and recent investigations have increased our understanding this process. Thyrotrope-specific proteins play a critical role expression, influence T3-mediated regulatory mechanisms. The structure placement the TREs define suppressive regulation by T3, process favored TR isoforms expressed pituitary. Elimination beta function compromises pituitary response to T3. 2, isoform specifically neural tissue, contains transferable domain that both increases T3-independent enhances T3-suppressed transcription. functional interaction 2 with other distinct from isoforms, likely plays physiology resistance hormone. development novel thyrotrope cell lines will allow investigators new molecular mechanisms distinguish negative positive transcriptional regulation.