Development of the nitrone-based spin trap agent NXY-059 to treat acute ischemic stroke.
作者： Paul A. Lapchak , Dalia M. Araujo
DOI: 10.1111/J.1527-3458.2003.TB00252.X
关键词:
摘要: The only current FDA-approved treatment for acute ischemic stroke is thrombolysis with tissue plasminogen activator (tPA). However, there are numerous shortcomings to tPA including an increased incidence of intracerebral hemorrhage (ICH) and a short therapeutic window (3-6 h). In recent years, studies have attempted identify new therapeutics that might be neuroprotective following strokes. Free radical scavenging spin trap agents been proposed as potential candidates therapy because the hypothesized role free radicals in progression ischemia-induced neurodegeneration. Novel like (disodium-[(tert-butylimino) methyl] benzene-1,3-disulfonate N-oxide (NXY-059) particular interest, not they broad-spectrum nitrone-based scavengers, but also their safety profile humans. Moreover, rationale developing NXY-059 further supported by drug's reported effects. addition, may represent useful adjunct tPA, since preclinical demonstrated increases lowers occurrence tPA-induced ICH.
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