Iodothyronine deiodinases and cancer.

摘要: Thyroid hormones (TH) regulate key cellular processes, including proliferation, differentiation, and apoptosis in virtually all human cells. Disturbances TH pathway the resulting deregulation of these processes have been linked with neoplasia. The concentrations peripheral tissues are regulated via activity iodothyronine deiodinases. There 3 types enzymes: type 1 2 deiodinases involved activation while deiodinase inactivates TH. Expression disturbed different According to limited number studies cancer cell lines mouse models changes intratumoral extratumoral T3 may influence proliferation rate metastatic progression. Recent findings showing that increased expression lead enhanced tumoral support idea deiodinating enzymes potential This review summarizes observations impaired types, published date, mechanisms behind alterations, regulation receptors, transforming growth factor-β, Sonic-hedgehog pathway. Possible roles as markers modulators tumor progression also discussed.