Lymphocyte activation provokes modification of a lymphocyte-specific protein tyrosine kinase (p56lck).

摘要: The protein tyrosine kinase p56lck is implicated in the control of lymphocyte growth by virtue its overexpression some lymphoid malignancies and transforming activity heterologous systems. Previous studies have demonstrated that levels lck mRNA decline rapidly after T cell activation. disappearance results primarily from post-translational conversion to more slowly migrating forms with apparent sizes approximately 60 kDa. This modification can be provoked treatment lymphocytes PMA, has been associated increased serine phosphorylation molecule. Here we demonstrate p60lck a feature physiologic activation antigen-presenting cells. In addition, show PMA-induced proceeds via mechanism distinct conventional C rapid antigenic stimulation consistent view this membrane-associated regulates aspects sequence.