MIR210HG promotes cell proliferation and invasion by regulating miR-503-5p/TRAF4 axis in cervical cancer.
作者： Ai-Hong Wang , Can-Hui Jin , Guan-Yi Cui , Hong-Yu Li , Yin Wang
关键词:
摘要: Long non-coding RNAs (lncRNAs) play important roles in the progression of cervical cancer (CC). However, and underlying molecular mechanisms lncRNAs CC remain unclear. In current study, we discovered a new lncRNA MIR210HG which was upregulated tissues through microarray. The upregulation associated with advanced FIGO stage, metastasis, poor prognosis patients. Function assays showed that inhibition significantly suppressed proliferation, invasion, epithelial-mesenchymal transition (EMT) processes reduced tumor growth vivo. Mechanistically, identified might serve as competing endogenous RNA (ceRNA) miR-503-5p to relieve repressive effect on TRAF4 expression cells. conclusion, demonstrated promoted regulating MIR210HG/miR-503-5p/TRAF4 axis, indicating act novel insight into treatment.
sci-hub.st 参考文章(28)
Julia Liz, Manel Esteller, lncRNAs and microRNAs with a role in cancer development. Biochimica et Biophysica Acta. ,vol. 1859, pp. 169- 176 ,(2016) , 10.1016/J.BBAGRM.2015.06.015
Regis Masson, Catherine H Régnier, Marie-Pierre Chenard, Corinne Wendling, Marie-Genevieve Mattei, Catherine Tomasetto, Marie-Christine Rio, TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 4 (TRAF4) EXPRESSION PATTERN DURING MOUSE DEVELOPMENT Mechanisms of Development. ,vol. 71, pp. 187- 191 ,(1998) , 10.1016/S0925-4773(97)00192-5
Alessandro Fatica, Irene Bozzoni, Long non-coding RNAs: new players in cell differentiation and development Nature Reviews Genetics. ,vol. 15, pp. 7- 21 ,(2014) , 10.1038/NRG3606
Hai-min Zhang, Feng-qiang Yang, Shao-Jun Chen, Jianping Che, Jun-hua Zheng, Upregulation of long non-coding RNA MALAT1 correlates with tumor progression and poor prognosis in clear cell renal cell carcinoma Tumor Biology. ,vol. 36, pp. 2947- 2955 ,(2015) , 10.1007/S13277-014-2925-6
Long Zhang, Fangfang Zhou, Amaya García de Vinuesa, Esther M. de Kruijf, Wilma E. Mesker, Li Hui, Yvette Drabsch, Yihao Li, Andreas Bauer, Adrien Rousseau, Kelly-Ann Sheppard, Craig Mickanin, Peter J.K. Kuppen, Chris X. Lu, Peter ten Dijke, TRAF4 Promotes TGF-β Receptor Signaling and Drives Breast Cancer Metastasis Molecular Cell. ,vol. 51, pp. 559- 572 ,(2013) , 10.1016/J.MOLCEL.2013.07.014
Eduardo L. Franco, Nicolas F. Schlecht, Debbie Saslow, The epidemiology of cervical cancer. Cancer Journal. ,vol. 9, pp. 348- 359 ,(2003) , 10.1097/00130404-200309000-00004
Tim R. Mercer, Marcel E. Dinger, John S. Mattick, Long non-coding RNAs: insights into functions Nature Reviews Genetics. ,vol. 10, pp. 155- 159 ,(2009) , 10.1038/NRG2521
Gaëlle A.V. Boulet, Caroline A.J. Horvath, Sarah Berghmans, Johannes Bogers, Human Papillomavirus in Cervical Cancer Screening: Important Role as Biomarker Cancer Epidemiology, Biomarkers & Prevention. ,vol. 17, pp. 810- 817 ,(2008) , 10.1158/1055-9965.EPI-07-2865
Ewan A Gibb, Carolyn J Brown, Wan L Lam, The functional role of long non-coding RNA in human carcinomas Molecular Cancer. ,vol. 10, pp. 38- 38 ,(2011) , 10.1186/1476-4598-10-38
Mark Schiffman, Philip E Castle, Jose Jeronimo, Ana C Rodriguez, Sholom Wacholder, Human papillomavirus and cervical cancer The Lancet. ,vol. 370, pp. 890- 907 ,(2007) , 10.1016/S0140-6736(07)61416-0