Interferon--a candidate mediator of cell growth.

摘要: Interferon (IFN) was originally discovered in 1958, when it found that extracts of virally infected cells conferred anti-viral resistance host cells.1 Since the discovery IFN, has become clear there are at least three antigenically defined families IFNs (IFN-β, IFN-γ, and IFN-α) such have diverse, pleiotropic effects on IFN receptor-bearing cells.2-3 Some these cell include modulation growth induction antigens Major Histocompatibility Complex (MHC). The ability s to stimulate expression MHC suggests they could be involved immunopathological responses tissues disease or injury. This may case for destruction islet γ diabetic pancreas4 demyelination CNS neurons multiple sclerosis.5 In this chapter, however, produce (and, make biological to) context normal developmental processes proliferation will used as a model illustrate scope action. Studies injury development molecular level might implications similar functions pancreas.6