Cocaine-induced place conditioning: importance of route of administration and other procedural variables.

摘要: It has been shown that pretreatment with dopamine (DA) receptor blockers disrupts the effect of intravenously (IV) and intracerebrally (ICV), but not intraperitoneally (IP) administered cocaine on place preference conditioning (PPC). The present study was undertaken to further evaluate possible differences between IV IP PPC. To this end, several factors which may differentially influence PPC were examined. Firstly, dose-response effects studied. Intravenous produced within a narrow dose range (0.5–2.5 mg/kg). Animals receiving injections 5 10 mg/kg experienced convulsions did show For 10-fold increase in (10 mg/kg) twice number training trials required order obtain equal magnitude (0.5 mg/kg; two trials). Cocaine retained at least 1 month. Following developed for side associated drug regardless whether or most preferred side. After cocaine, only when paired Rats trained IV, IP, significantly familiar novel compartment. Preference testing carried out drugged undrugged state, excluding state-dependent as an explanation results procedure be valid test evaluating rewarding properties cocaine. However, they fail