Enantioselective Synthesis of Near Enantiopure Compound by Asymmetric Autocatalysis Triggered by Asymmetric Photolysis with Circularly Polarized Light

摘要: Right- and left-handed circularly polarized light (CPL) has been proposed as one of the origins homochirality biomolecules. However, enantiomeric excess induced by CPL only very low ( 99.5% ee. On other hand, irradiation with l-CPL affords (S)-pyrimidyl alkanol >99.5% Thus, chiral physical power, such CPL, in conjunction asymmetric autocatalysis, provides a highly enantioenriched compound.