A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample.

摘要: Background In the present study we investigated genetic variants associated with bipolar disorder in a homogenous Norwegian sample, and potential overlap schizophrenia, using Affymetrix 6.0 array. Methods We carried out genome-wide association (GWAS) by genotyping 620 390 single-nucleotide polymorphisms (SNPs) case-control sample of origin (the TOP study) including (n = 194), healthy controls (n = 336) schizophrenia (n = 230), followed replication combined analysis genetically concordant Icelandic (n = 435), (n = 10,258). Results We selected 1000 markers lowest P values discovery GWAS tested these (or their surrogates) for sample. Polymorphisms on 35 loci were confirmed (nominal value < 0.05; not corrected multiple testing) The most significant located DLEU2, GUCY1B2, PKIA, CCL2, CNTNAP5, DPP10, FBN1. group compared to did provide additional findings. Limitations Relatively small number samples. Conclusions We detected weak but reproducible several genes, proximity susceptibility found previous studies disorder. Further work is required localization, expression, regulation international meta-analytic efforts will help further elucidate role.