Increased wound-breaking strength induced by insulin-like growth factor I in combination with insulin-like growth factor binding protein-1.

摘要: BACKGROUND Polypeptide growth factors have been shown to accelerate wound repair in rodent animal model systems. METHODS In this report, insulin-like factor I (IGF-I) and the combination of IGF-I plus binding protein (IGFBP-1) were applied directly linear incisions made through dorsal rat skin, histologic analysis breaking strength hydroxyproline quantification performed. RESULTS alone, contrast transforming factor-beta platelet-derived factor, had no effect on wound-breaking strength. However, IGFBP-1 significantly increased Wound-breaking was 33% compared with wounds treated alone. alone effect. The ability stimulate dependent posttranslation modification IGFBP-1. Phosphorylated without effect, whereas dephosphorylated fully biologically active. This increase induced by accompanied an 67% content, phosphorylated form CONCLUSIONS We concluded that is a potent stimulant incisional healing, but if administered other factors, its effects can only be when it combined one specific proteins.