Strategies for improving plasmid stability in genetically modified bacteria in bioreactors
作者： PKR Kumar , HE Maschke , Karl Friehs , K Schügerl
DOI: 10.1016/0167-7799(91)90090-5
关键词:
摘要: Exploitation of recombinant organisms for the large-scale, commercial production foreign proteins is often hampered by problem plasmid instability. A wide range strategies have been reported improving stability organisms. combination manipulating both genetic design recombinants and conditions culturing may be used to achieve stable host-vector associations during culture in bioreactors.
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