HLA-Cw*0409N is associated with HLA-A*2301 and HLA-B*4403-carrying haplotypes.
作者： C Pinto , A.G Smith , C.E Larsen , M Fernández-Viña , Z Husain
DOI: 10.1016/J.HUMIMM.2003.11.001
关键词:
摘要: The associations of HLA-B*4402 and HLA-B*4403 with alleles HLA-A HLA-Cw were investigated in panels homozygous individuals selected carrying HLA-Cw*04 HLA-B*4403. Some these genotyped also carried (HLA-DRB1*0701, DQB1*02). Among the latter, we studied conserved extended haplotype (CEH) [HLA-Cw*04, B*4403, FC31, DRB1*0701, DQB1*02]. Four different common (HLA-Cw*, B*44) haplotypes identified that to locus: HLA-A*0201, Cw*0501, B*4402; HLA-A*2902, Cw*1601, B*4403; HLA-A*2301, Cw*0401, Cw*0409N, B*4403. We eight unrelated examples allele HLA-Cw*0409N. HLA-A*2301 was associated both HLA-Cw*0401 HLA-Cw*0409N, suggesting HLA-Cw*0409N may have arisen from a mutation CEH. estimate approximately 2 5 1000 Caucasian carry making it one most frequent null HLA known date. Our findings demonstrate first example three HLA-Cw-determined subtypes or CEH shared HLA-B allele, this case
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