MIR146A inhibits JMJD3 expression and osteogenic differentiation in human mesenchymal stem cells
作者： Jessica M. Huszar , Christopher J. Payne
DOI: 10.1016/J.FEBSLET.2014.03.057
关键词:
摘要: Chromatin remodeling is important for cell differentiation. Histone methyltransferase EZH2 and histone demethylase JMJD3 (KDM6B) modulate levels of H3 lysine 27 trimethylation (H3K27me3). Interplay between the two modulators influence lineage specification in stem cells. Here, we identified microRNA MIR146A to be a negative regulator JMJD3. In osteogenic differentiation human mesenchymal cells (hMSCs), observed an upregulation downregulation MIR146A. Blocking activity differentiating hMSCs reduced transcript gene RUNX2. H3K27me3 decreased at RUNX2 promoter during Modulation altered expression affected We conclude that promotes osteogenesis hMSCs, with regulating
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