ROLE OF INTERLEUKIN-1BETA IN SUPEROVULATION IN RATS
作者： MIOKO ONO , YASUHIKO NAKAMURA , HIROSHI TAMURA , SHUJI TAKIGUCHI , NORIHIRO SUGINO
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摘要: In this study, the changes in interleukin-1beta (IL-1beta) mRNA expression and its localization ovary were studied pregnant mares' serum gonadotropin (PMSG)-human CG (hCG) injected immature rats. Moreover, to study vivo role of IL-1 during ovulation, receptor antagonist (IL-1ra) was into bilateral bursae (100 microg/15 microl/bursa) immediately or at 3rd, 5th, 10th h after hCG injection. IL-1beta had significantly (P<0.05) increased 6th injection, level depended on time interval between PMSG injections; maximal observed when 48 The signals localized thecal layer, particularly large preovulatory follicles. Intrabursal IL-1ra injection 3rd showed a trend toward lowering number ova shed, 5th (P<0.01) decreased shed compared with saline control group. At 24th there few follicles distinguishable theca granulosa layers treated ovary, although these two indistinguishable ovary. These results indicated that definitely induced by stimulation, and, moreover, dependent stage follicular maturation. may be important for ovulation superovulatory cycle
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