In silico Strategies to Support Fragment-to-Lead Optimization in Drug Discovery.
作者： Lauro Ribeiro de Souza Neto , José Teófilo Moreira-Filho , Bruno Junior Neves , Rocío Lucía Beatriz Riveros Maidana , Ana Carolina Ramos Guimarães
关键词:
摘要: … parallel screening by X-ray crystallography of individually soaked fragments. In this review … support the follow-up fragment-to-lead optimization of either: growing, linking, and merging. …
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