Diagnosis of penicillin allergy by skin testing: the Manitoba experience

摘要: The reliability of skin testing in the diagnosis penicillin allergy was studied 86 adults and 167 children with a history possible hypersensitivity reactions to penicillin. Skin done major antigenic determinant benzylpenicillin minor determinants benzylpenicillin, ampicillin, cloxacillin, methicillin cephalothin. overall frequency positive 11.5%. Among patients about half had immediate or accelerated penicillins, but 2 11 50% this group maculopapular rash delayed onset. There low when there long interval between times clinical reaction testing. Of 169 reacting negatively who received specific drug challenge only manifested mild urticaria; indicates tests predicting allergy. were most useful reagents. One fifth would have been missed if alone used for additional use other derivatives, however, did not increase substantially procedure.