Adrenal, kidney, and heart angiotensins in female murine ren-2 transfected hypertensive rats
作者： P.deS Senanayake , R.R Smeby , A.S Martins , A Moriguchi , H Kumagai
DOI: 10.1016/S0196-9781(98)00123-5
关键词:
摘要: We analyzed by high-performance liquid chromatography and radioimmunoassay angiotensin I (Ang I), Ang II, Ang-(1-7), metabolites in the adrenal, kidney heart of normotensive female Sprague-Dawley (SD) transgenic hypertensive [TGR(mRen-2)27] rats carrying murine Ren-2d renin gene. The monogenetic model had significant increases adrenal II; whereas II was unchanged, but Ang-(1-7) were significantly lower. Cardiac I, Ang-(2-10) reduced rats, while Ang-(2-7) increased. In SD angiotensins increased primarily during estrus or proestrus. sustained renal may contribute to established phase hypertension.
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