Molecular-targeted nanorods for the localised destruction of cancer cells

摘要: Nanorods are used to improve the signal-to-noise ratio of thermoelastic emissions from tissue and can be functionalised with molecular-targeting ligands specifically targeted cancer cells, for both imaging therapeutic applications. By simultaneously illuminating these nanorods whilst they under tension an ultrasound field, localised inertial cavitation is generated at significantly lower laser fluence pressure thresholds than either mechanisms alone. The broadband acoustic emission collapse detected, where it has been shown that magnitude over order greater alone thus have a depth penetration. As driven by peak field sufficiently violent result in destruction cells. This study nucleation threshold vapour bubbles around gold decreased increasing but were dominated pressures used. A cell population had incubated un-targeted was imaged using collapse, which exposure levels 2.65 MPa 1.5 mJ/cm2 resulted cells becoming un-viable.