Assessing disease-modifying effects of norepinephrine in Down syndrome and Alzheimer’s disease

摘要: Abstract Building upon the knowledge that a number of important brain circuits undergo significant degeneration in Alzheimer’s disease, numerous recent studies suggest norepinephrine-ergic system brainstem undergoes alterations early course both disease and Down syndrome. Massive projections from locus coeruleus neurons to almost entire brain, extensive innervation capillaries, widespread distribution noradrenergic receptors enable play crucial role neural processes, including cognitive function. These anatomical functional characteristics support as an target for developing new therapies dysfunction. Careful neuropathological examinations using postmortem samples individuals with have implicated etiopathogenesis disease. Furthermore, supported existence strong interaction between neuroimmune systems. We explore two systems could disease-modifying effects norepinephrine