Isolation and Characterization of Plasma Lipoproteins and Apolipoproteins

摘要: The plasma lipoproteins are the major carriers of lipid in circulation. Structurally, these particles represent a microemulsion triglyceride and cholesteryl ester stabilized by polar surface phospholipid, cholesterol, protein (Bradley Gotto, 1978; Morrisett et al., 1977). Four classes have been designated on basis their ultracentrifugal flotation properties salt solutions. These chylomicrons, very-low-density (VLDL), low-density (LDL), high-density (HDL). Chylomicrons VLDL float at d < 1.006 g/ml. LDL isolated between = 1.02 1.063 g/ml, HDL to 1.210 Although classification based ultracentrifugation solutions has proven be useful nomenclature, each density ranges actually contains complex mixture varying composition. physical chemical human summarized Table I. contain primarily triglycerides as neutral lipid, whereas esters phospholipids.