The Human MHC (HLA) and Its Immediate Relevance in Transfusion Practice

摘要: The human major histocompatibility complex (MHC) or HLA (human lymphocyte antigens) has a role in the functioning of immune system at several key points. presence these antigens was first recognized mice by pioneering work Snell and his colleagues, who, mid-1930s, realized that were some way related to rejection experimental skin allografts animals. In early 1950s, similar group humans independently discovered Daussett France Payne United States. Netherlands, van Rood contributed elucidation actual genetic systems involved MHC characterization sera from multiparous women so tentative specificities could be assigned. A series regular international workshops have continued this painstaking paved for detection loci within MHC. These also stimulated much on establishment clinical relevance fields organ transplantation predisposition specific diseases.