Gum arabic establishes prebiotic functionality in healthy human volunteers in a dose-dependent manner.

作者: Wim Calame , Antje R. Weseler , Christer Viebke , Cal Flynn , André D. Siemensma

DOI: 10.1017/S0007114508981447

关键词:

摘要: The present study was undertaken to determine the prebiotic efficacy of gum arabic upon consumption by man for up 4 weeks and, if any, establish dose-effect relationship. Human healthy volunteers consumed various daily doses (5, 10, 20, 40 g) (EmulGold) in water weeks. Daily taken as negative control and that 10 g inulin positive control. At 0, 1, 2 quantification bacterial numbers stool samples performed via real time-PCR techniques questionnaires were filled account potential drawbacks. genera Bifidobacteria Lactobacilli potentially beneficial bacteria those Bacteroides, Clostridium difficile Enterococci non-beneficial, this distinction dependent on issue these being or becoming out balance host. Compared with after significantly higher arabic: optimal dose around g. Moreover, at Bifidobacteria, Bacteroides than inulin. No significant drawback encountered during study. It is concluded establishes efficacy, least good found be

参考文章(31)
Khalil U. Rehman, Champa N. Codipilly, Raul A. Wapnir, Modulation of small intestinal nitric oxide synthase by gum arabic. Experimental Biology and Medicine. ,vol. 229, pp. 895- 901 ,(2004) , 10.1177/153537020422900905
Geoffrey Annison, Rodney P. Trimble, David L. Topping, Feeding Australian Acacia gums and gum arabic leads to non-starch polysaccharide accumulation in the cecum of rats. Journal of Nutrition. ,vol. 125, pp. 283- 292 ,(1995) , 10.1093/JN/125.2.283
G. O. Phillips, P. A. Williams, Handbook of hydrocolloids. Handbook of hydrocolloids.. ,(2009) , 10.1533/9781845695873
John H Cummings, George T Macfarlane, Hans N Englyst, Prebiotic digestion and fermentation The American Journal of Clinical Nutrition. ,vol. 73, ,(2001) , 10.1093/AJCN/73.2.415S
H F Guiot, Role of competition for substrate in bacterial antagonism in the gut. Infection and Immunity. ,vol. 38, pp. 887- 892 ,(1982) , 10.1128/IAI.38.3.887-892.1982
Christopher Duggan, Jennifer Gannon, W Allan Walker, Protective nutrients and functional foods for the gastrointestinal tract. The American Journal of Clinical Nutrition. ,vol. 75, pp. 789- 808 ,(2002) , 10.1093/AJCN/75.5.789
Hans-P. Kruse, Brigitta Kleessen, Michael Blaut, Effects of inulin on faecal bifidobacteria in human subjects. British Journal of Nutrition. ,vol. 82, pp. 375- 382 ,(1999) , 10.1017/S0007114599001622
Glenn R. Gibson, Marcel B. Roberfroid, Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics Journal of Nutrition. ,vol. 125, pp. 1401- 1412 ,(1995) , 10.1093/JN/125.6.1401
Joy M. Campbell, George C. Fahey, Carol A. Lichtensteiger, Stephen J. Demichele, Keith A. Garleb, An Enteral Formula Containing Fish Oil, Indigestible Oligosaccharides, Gum Arabic and Antioxidants Affects Plasma and Colonic Phospholipid Fatty Acid and Prostaglandin Profiles in Pigs The Journal of Nutrition. ,vol. 127, pp. 137- 145 ,(1997) , 10.1093/JN/127.1.137
David J. A. Jenkins, Cyril W. C. Kendall, Vladimir Vuksan, Inulin, Oligofructose and Intestinal Function Journal of Nutrition. ,vol. 129, pp. 1431- 1433 ,(1999) , 10.1093/JN/129.7.1431S