CYTOTOXIC AND MUTAGENIC EFFECTS OF IRRADIATED SUBSTRATES AND FOOD MATERIAL.

摘要: The lethal effects of both ionizing and non-ionizing radiations have many potentially important applications in food technology. To capitalize on this use, a pre-requisite is the clear establishment absence undesirable secondary irradiated material. Commencing from study Stone, Wyss Haas (150) who found that U.V.-irradiated substrate itself induces mutations Staphylococcus aureus , numerous studies been carried out to ascertain whether cytotoxic occur when unirradiated biological test systems are cultured or fed with media food. In such studies, adverse physiological (growth retardation inhibition), cytological (mitotic inhibition chromosome aberrations) genetical (forward reverse mutations) observed wide range systems, ranging bacteriophages human cells. These very small frequency occurrence compared those exposed directly radiation. Consequently, they can be demonstrated primarily by statistical comparisons control populations. yield longevity principle generated dose-dependent. On other hand, genetic do not show any well defined relationship dose also vary even within same organism as Drosophila melanogaster . containing glucose, glucose component seems particularly prone radiation reference production mutagenic products. some addition catalase neutralized effects, while others, were influenced catalase. It likely hydrogen peroxide plays an intermediate role formation various toxic derivatives. available data suggest peroxide, glyoxal, formic acid, hydroxyalkyl peroxides, histidine-peroxide adduct deoxycompounds may act agents different systems. bulk now field relate somatic effects. gathered conflicting, E. coli there conclusive evidence media. order understand fully bearing these findings nutrition, critical experiments mice urgently needed.