The effect of topical administration of atropine sulfate on the normal equine pupil: influence of age, breed and gender.

摘要: Objectives  The purpose of this study was to determine the influence age, breed and gender on vertical pupil diameter (VPD) following a single dose 1% atropine sulfate ophthalmic solution in normal equine eye. Animals studied  Thirty-two horses various ages, breeds genders were included. had no history or clinical signs disease. All studied darkly pigmented irides. Procedures  Two milligrams topically administered as right eye each horse Day 0. VPD (mm) measured both eyes using digital calipers prior treatment every 24 h after administration for 2 weeks (Days 1–14). Duration effect then calculated treated untreated eyes. Data also analyzed mean VPD, maximum time VPD. Results significantly elevated compared baseline measurements at all points. Arabians greater 0 several days treatment. Females males 5 out 15 days. Conclusions  mydriasis is than 14 days. Horses Arabian female may be more sensitive effects cholinergic blockade eye.